The neem tree is native to both India and Burma. The seeds, leaves, and bark of the neem tree are all useful therapeutically.The native peoples of India have used Neem and Neem extracts for hundreds of years.  Before toothpaste was introduced, Indians chewed neem twigs to effectively keep their teeth healthy.  Neem extract has been added to several commercial toothpaste's to prevent tooth decay and to prevent and heal gum inflammations.